Download e-book for iPad: Modelling the Short QT Syndrome Gene Mutations: And Their by Ismail Adeniran

By Ismail Adeniran

The brief QT Syndrome (SQTS) is characterised through abbreviated QT periods at the electrocardiogram, elevated possibility of cardiac arrhythmias and unexpected dying. even if a number of gene mutations were pointed out in SQT sufferers, the position of those mutations in selling arrhythmogenesis remains to be now not thoroughly understood. for that reason, this thesis employs multidisciplinary ways to enhance a 3D digital center, that's then used to explain how the fast QT syndrome enables and continues ventricular arrhythmias and to figure out its results on ventricular mechanical contraction. The findings during this thesis supply a entire and mechanistic reason behind a few gene mutations linked to potassium channels when it comes to susceptibility to arrhythmia. The multiphysics versions constructed offer a strong platform for picking the basis explanations of varied arrhythmias and investigating healing interventions for those diseases.

The thesis was once tested by way of Prof. Chris Huang of the collage of Cambridge, the main authoritative determine in cardiac electrophysiology, who has defined the paintings as “outstanding.”

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Modelling the Short QT Syndrome Gene Mutations: And Their Role in Cardiac Arrhythmogenesis (Springer Theses) by Ismail Adeniran

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